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Mayo Clin Proc. Rapid resolution of delusional parasitosis in pellagra with niacin augmentation therapy. Gen Hosp Psychiatry. Badawy AA. Pellagra and alcoholism: a biochemical perspective. Alcohol Alcohol. Overview of the role of vitamins and minerals on the kynurenine pathway in health and disease.

J Physiol Pharmacol. Letter: Pellagra as the initial presentation of Crohn disease. Dermatol Online J. A case of pellagra associated with megaduodenum in a young woman. Nutr Clin Pract.

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Isoniazid-induced pellagra. Cutan Ocul Toxicol. Natural Medicines. Nutritional deficiencies in patients receiving cancer chemotherapy. Postgrad Med. Pellagra associated with esophageal carcinoma and alcoholism. Oldham MA, Ivkovic A. Pellagrous encephalopathy presenting as alcohol withdrawal delirium: a case series and literature review. Addict Sci Clin Pract. Pellagra and its prevention and control in major emergencies. World Health Organization. Murray MF. Tryptophan depletion and HIV infection: a metabolic link to pathogenesis.

Lancet Infect Dis. Food and Nutrition Board, Institute of Medicine. Washington, D. The National Academies Press. Genomic instability--an evolving hallmark of cancer. Nat Rev Mol Cell Biol. Niacin requirements for genomic stability. Mutat Res. Burkle A. Poly ADP-ribose. FEBS J. Mapping the role of NAD metabolism in prevention and treatment of carcinogenesis. Mol Cell Biochem. Niacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cells. Nutr Cancer. Niacin deficiency increases spontaneous and etoposide-induced chromosomal instability in rat bone marrow cells in vivo.

Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow.

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Dantzer F, Santoro R. The expanding role of PARPs in the establishment and maintenance of heterochromatin. Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes. Niacin deficiency decreases bone marrow poly ADP-ribose and the latency of ethylnitrosourea-induced carcinogenesis in rats. J Nutr. Pharmacological intakes of niacin increase bone marrow poly ADP-ribose and the latency of ethylnitrosourea-induced carcinogenesis in rats. Weitberg AB. Effect of nicotinic acid supplementation in vivo on oxygen radical-induced genetic damage in human lymphocytes.

Nicotinic acid supplementation: effects on niacin status, cytogenetic damage, and poly ADP-ribosylation in lymphocytes of smokers. High dietary niacin intake is associated with decreased chromosome translocation frequency in airline pilots. Br J Nutr. DNA Repair Amst. Jacobson EL. Niacin deficiency and cancer in women. J Am Coll Nutr. Selected micronutrients and oral and pharyngeal cancer. Int J Cancer. Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus. Oral niacin prevents photocarcinogenesis and photoimmunosuppression in mice.

A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin. Exp Dermatol. Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. PLoS One. Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. Niacin intake and risk of skin cancer in US women and men. A phase 3 randomized trial of nicotinamide for skin-cancer chemoprevention. Melanoma and nonmelanoma skin cancer chemoprevention: A role for nicotinamide? Photodermatol Photoimmunol Photomed.

Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care. Szkudelski T. Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model.

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Exp Biol Med Maywood. The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes. Nicotinamide reduces high secretion of IFN-gamma in high-risk relatives even though it does not prevent type 1 diabetes. J Interferon Cytokine Res. Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide - Case reports. J Pediatr Endocrinol Metab.

Hartnup disease. Indian J Dermatol. Oakley A, Wallace J. Hartnup disease presenting in an adult. Clin Exp Dermatol. NAD deficiency, congenital malformations, and niacin supplementation. Vander Heiden MG. Metabolism and congenital malformations - NAD's effects on development. J Inherit Metab Dis. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity increased K m : relevance to genetic disease and polymorphisms.

Am J Clin Nutr. Am J Cardiovasc Drugs. Effect of very-low-dose niacin on high-density lipoprotein in patients undergoing long-term statin therapy. Am Heart J. Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol ARBITER 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Relationship between glycemic status and progression of carotid intima-media thickness during treatment with combined statin and extended-release niacin in ARBITER 2.

Vasc Health Risk Manag. J Am Coll Cardiol. Flow-mediated dilation and cardiovascular risk prediction: a systematic review with meta-analysis.

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Int J Cardiol. Sahebkar A. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials. Vasc Med. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease.

Niacin plus simvastatin reduces coronary stenosis progression among patients with metabolic syndrome despite a modest increase in insulin resistance: a subgroup analysis of the HDL-Atherosclerosis Treatment Study HATS. J Clin Lipidol. Safety and tolerability of simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol The HDL Atherosclerosis Treatment Study.


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  4. Am J Cardiol. Effects of niacin on the incidence of new onset diabetes and cardiovascular events in patients with normoglycaemia and impaired fasting glucose. Int J Clin Pract. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.

    Effect of extended-release niacin on cardiovascular events and kidney function in chronic kidney disease: a post hoc analysis of the AIM-HIGH trial. Kidney Int. Effects of extended-release niacin with laropiprant in high-risk patients. Niacin for primary and secondary prevention of cardiovascular events. Cochrane Database Syst Rev. Use of niacin in the United States and Canada. Burk K. Friedreich ataxia: current status and future prospects. Cerebellum Ataxias. Hum Mol Genet. Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.

    Nicotinamide in Friedreich's ataxia: useful or not? Taylor EW. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.